Anti-Integrin beta-3

Code: AB2984 D2-231

Analysis Note

ControlU251 cell lysate

Application

Immunohistochemistry Analysis: A 1:500 dilution from a previous lot detected intergin beta-3 in...


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Analysis Note

ControlU251 cell lysate

Application

Immunohistochemistry Analysis: A 1:500 dilution from a previous lot detected intergin beta-3 in skin membrane tissue.

Immunoprecipitaiton Analysis: 10 µg from a previous lot immunoprecipitated integrin beta-3 from U251 RIPA lysate.

Anti-Integrin beta-3 Antibody is an antibody against Integrin beta-3 for use in WB, IP, IH(P).

Research CategoryCell Structure

Research Sub CategoryECM Proteins

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Integrin beta-3 is a member of the Integrin receptor family. The integrin family has been shown to be instrumental in cell adhesion to extracellular matrix proteins and can be found in certain cell to cell adhesions. Integrins are also important in transmembrane connections and intracellular signaling. Integrins are key to understanding many human diseases as they are commonly the receptors. Integrins have been linked to many different parts of cellular operations including; development, immunity, leukocyte traffic, homeostasis and even cancer. Once integrin beta-3 is activated, it binds fibrinogen which causes platelet to platelet interaction effectively cutting off a ruptured endothelial surface.

Immunogen

KLH-conjugated linear peptide corresponding to human integrin beta-3 at the extracellular domain.

Epitope: Extracellular Domain

Linkage

Replaces: 04-1060

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Quality

Evaluated by Western Blot in U251 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected integrin beta-3 in 10 µg of U251 cell lysate.

Specificity

This antibody recognizes the extracellular domain of integrin beta-3.

Other homologies: Mouse (93% sequence homology.)

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~85 kDa observed.
Uncharacterized bands may be observed in some lysates.

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
Gene Informationhuman ... ITGB3(3690)
NCBI accession no.NP_000203
purified byaffinity chromatography
Quality Level100
shipped inwet ice
species reactivity (predicted by homology)porcine (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), bovine (based on 100% sequence homology), canine (based on 100% sequence homology), rat (based on 100% sequence homology)
species reactivitypig, human
technique(s)western blot: suitable, immunohistochemistry: suitable (paraffin), immunoprecipitation (IP): suitable
UniProt accession no.P05106
This product has met the following criteria to qualify for the following awards:



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